Anti-LFA3 antibody [HI58a] (CF405M) (ab117738)

Overview

  • Product nameAnti-LFA3 antibody [HI58a] (CF405M)
    See all LFA3 primary antibodies
  • Description
    Mouse monoclonal [HI58a] to LFA3 (CF405M)
  • ConjugationCF405M. Ex: 408nm, Em: 452nm
  • Specificityab117738 is recommended for use in flow cytometry for identification of erythrocytes, platelets, monocytes, bone marrow cells, a lymphocyte subset and epithelial and endothelial cells.
  • Tested applicationsSuitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Peripheral Blood Mononuclear Cell

  • Positive control
    • Normal Human peripheral blood cells
  • General notes


    ab117738 recognizes the Human CD58 cell surface antigen. CD58 is a cell adhesion molecule, which plays a critical role in facilitation of antigen specific recognition through interaction with CD2 on T lymphocytes. It is a member of the immunoglobulin superfamily of molecules. CD58 has a wide tissue distribution, being present on erythrocytes, platelets, monocytes, a subset of lymphocytes, bone marrow cells, epithelium, and endothelial cells. There are approximately 5,000 CD58 molecules on each erythrocyte. There is reduced expression of CD58 on haemopoietic cells in individuals with paroxysmal nocturnal haemoglobinuria

    CF405M (Abs/Em Max: 408/450nm). Direct replacement for Pacific Blue dye®, BD Horizon™ V450.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C.
  • Storage bufferpH: 7.20
    Preservative: 0.09% Sodium azide
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Primary antibody notesab117738 recognizes the Human CD58 cell surface antigen. CD58 is a cell adhesion molecule, which plays a critical role in facilitation of antigen specific recognition through interaction with CD2 on T lymphocytes. It is a member of the immunoglobulin superfamily of molecules. CD58 has a wide tissue distribution, being present on erythrocytes, platelets, monocytes, a subset of lymphocytes, bone marrow cells, epithelium, and endothelial cells. There are approximately 5,000 CD58 molecules on each erythrocyte. There is reduced expression of CD58 on haemopoietic cells in individuals with paroxysmal nocturnal haemoglobinuria
  • ClonalityMonoclonal
  • Clone numberHI58a
  • IsotypeIgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab117738 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use 5µl for 106 cells. ab126026-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Target

  • FunctionLigand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.
  • Sequence similaritiesContains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Cellular localizationCell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • AG3 antibody
    • CD58 antibody
    • CD58 antigen (lymphocyte function associated antigen 3)1 antibody
    • CD58 antigen antibody
    • CD58 antigen, (lymphocyte function associated antigen 3) antibody
    • CD58 molecule antibody
    • FLJ23181 antibody
    • FLJ43722 antibody
    • LFA 3 antibody
    • LFA-3 antibody
    • LFA3 antibody
    • LFA3_HUMAN antibody
    • Lymphocyte Function Associated Antigen Type 3 antibody
    • Lymphocyte function-associated antigen 3 antibody
    • Surface glycoprotein LFA 3 antibody
    • Surface glycoprotein LFA-3 antibody
    see all

Anti-LFA3 antibody [HI58a] (CF405M) images

  • Staining of normal Human peripheral blood cells with ab117738. Cells in the Lymphocytes gate were used for analysis (red histogram).

References for Anti-LFA3 antibody [HI58a] (CF405M) (ab117738)

ab117738 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"