Overview

  • Product name
    LH 846
  • Description
    Potent, selective CK1δ inhibitor
  • Biological description
    Potent, selective CK1δ inhibitor (IC50 values are 0.29, 1.3 and 2.5 μM for CK1δ, ε and α, respectively). Induces period lengthening of the circadian rhythm in U2OS cells.
  • Purity
    > 98%

Properties

  • Chemical name
    N-(5-Chloro-6-methyl-1,3-benzothiazol-2-yl)-2-phenylacetamide
  • Molecular weight
    316.80
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C16H13ClN2OS
  • CAS Number
    639052-78-1
  • PubChem identifier
    851474
  • Storage instructions
    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CC1=CC2=C(C=C1Cl)N=C(S2)NC(=O)CC3=CC=CC=C3
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Lee JW  et al. A small molecule modulates circadian rhythms through phosphorylation of the period protein. Angew Chem Int Ed Engl 50:10608-11 (2011). Read more (PubMed: 21954091) »

See 0 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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