Overview

  • Product name
  • Description
    Mouse polyclonal to LILRB1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein, corresponding to amino acids 1-650 of Human LILRB1

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    pH: 7.20
    Constituent: PBS
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab67532 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    WB: 1/500 - 1/1000. Predicted molecular weight: 71 kDa.
    Detection Pair

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
    • Tissue specificity
      Expressed predominantly on B-cells and monocytes, and at lower levels on dendritic cells. Detected on a low percentage of T-cells and natural killer (NK) cells.
    • Sequence similarities
      Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
    • Domain
      Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
    • Post-translational
      modifications
      Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.
    • Cellular localization
      Membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • CD85 antibody
      • CD85 antigen antibody
      • CD85 antigen like family member J antibody
      • CD85 antigen-like family member J antibody
      • CD85j antibody
      • CD85j antigen antibody
      • Ig like transcript 2 antibody
      • ILT 2 antibody
      • ILT-2 antibody
      • ILT2 antibody
      • immunoglobulin like transcript 2 antibody
      • Immunoglobulin-like transcript 2 antibody
      • leukocyte Ig like receptor 1 antibody
      • Leukocyte immunoglobulin like receptor 1 antibody
      • leukocyte immunoglobulin like receptor subfamily B member 1 antibody
      • Leukocyte immunoglobulin like receptor subfamily B member 1 precursor antibody
      • leukocyte immunoglobulin like receptor subfamily B member 1 soluble isoform antibody
      • leukocyte immunoglobulin like receptor, subfamily B, member 1 antibody
      • Leukocyte immunoglobulin-like receptor 1 antibody
      • Leukocyte immunoglobulin-like receptor subfamily B member 1 antibody
      • leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoform antibody
      • leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 antibody
      • LILRB1 antibody
      • LIR 1 antibody
      • LIR-1 antibody
      • LIR1 antibody
      • LIRB1_HUMAN antibody
      • MIR 7 antibody
      • MIR-7 antibody
      • MIR7 antibody
      • Monocyte/macrophage immunoglobulin like receptor 7 antibody
      • Monocyte/macrophage immunoglobulin-like receptor 7 antibody
      • PIR B antibody
      • PIRB antibody
      see all

    Images

    • All lanes : Anti-LILRB1 antibody (ab67532) at 1/500 dilution

      Lane 1 : LILRB1 transfected cell lysate
      Lane 2 : Non-transfected cell lysate

      Lysates/proteins at 25 µg per lane.

      Secondary
      Goat Anti-Mouse IgG (H&L)-HRP conjugated at 1/2500 dilution

      Predicted band size : 71 kDa

    References

    ab67532 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab67532.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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