Overview

  • Product name
    Anti-LILRB1 antibody [GHI/75]
    See all LILRB1 primary antibodies
  • Description
    Mouse monoclonal [GHI/75] to LILRB1
  • Host species
    Mouse
  • Tested applications
    Suitable for: Blocking, IP, WB, Functional Studies, Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Tissue, cells or virus corresponding to Human LILRB1. Hairy cell leukaemia cells
    Database link: Q8NHL6

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    pH: 7.4
    Preservative: 0.097% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
    Monoclonal
  • Clone number
    GHI/75
  • Isotype
    IgG2b
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab185325 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Blocking Use at an assay dependent concentration.

Blocking HLA-G induced TGF-beta1 production

IP Use at an assay dependent concentration.
WB Use at an assay dependent concentration.
Functional Studies Use at an assay dependent concentration.
Flow Cyt Use at an assay dependent concentration.

ab170192 - Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody.

 

Target

  • Function
    Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
  • Tissue specificity
    Expressed predominantly on B-cells and monocytes, and at lower levels on dendritic cells. Detected on a low percentage of T-cells and natural killer (NK) cells.
  • Sequence similarities
    Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
  • Domain
    Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Post-translational
    modifications
    Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD85 antibody
    • CD85 antigen antibody
    • CD85 antigen like family member J antibody
    • CD85 antigen-like family member J antibody
    • CD85j antibody
    • CD85j antigen antibody
    • Ig like transcript 2 antibody
    • ILT 2 antibody
    • ILT-2 antibody
    • ILT2 antibody
    • immunoglobulin like transcript 2 antibody
    • Immunoglobulin-like transcript 2 antibody
    • leukocyte Ig like receptor 1 antibody
    • Leukocyte immunoglobulin like receptor 1 antibody
    • leukocyte immunoglobulin like receptor subfamily B member 1 antibody
    • Leukocyte immunoglobulin like receptor subfamily B member 1 precursor antibody
    • leukocyte immunoglobulin like receptor subfamily B member 1 soluble isoform antibody
    • leukocyte immunoglobulin like receptor, subfamily B, member 1 antibody
    • Leukocyte immunoglobulin-like receptor 1 antibody
    • Leukocyte immunoglobulin-like receptor subfamily B member 1 antibody
    • leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoform antibody
    • leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 antibody
    • LILRB1 antibody
    • LIR 1 antibody
    • LIR-1 antibody
    • LIR1 antibody
    • LIRB1_HUMAN antibody
    • MIR 7 antibody
    • MIR-7 antibody
    • MIR7 antibody
    • Monocyte/macrophage immunoglobulin like receptor 7 antibody
    • Monocyte/macrophage immunoglobulin-like receptor 7 antibody
    • PIR B antibody
    • PIRB antibody
    see all

References

ab185325 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab185325.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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