Anti-LILRB2 antibody [27D6] (FITC) (ab95819)

Overview

  • Product name
    Anti-LILRB2 antibody [27D6] (FITC)
    See all LILRB2 primary antibodies
  • Description
    Rat monoclonal [27D6] to LILRB2 (FITC)
  • Conjugation
    FITC. Ex: 493nm, Em: 528nm
  • Tested applications
    Suitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    LILRB2-transfected RBL cells

  • Positive control
    • Normal Human peripheral blood cells

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C.
  • Storage buffer
    Preservative: 0.09% Sodium Azide
    Constituents: PBS, BSA, Gelatin, pH 7.2
  • Concentration information loading...
  • Purity
    Protein G purified
  • Clonality
    Monoclonal
  • Clone number
    27D6
  • Isotype
    IgM
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab95819 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use 5µl for 106 cells. ab35774-Rat monoclonal IgM, is suitable for use as an isotype control with this antibody.

Target

  • Function
    Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
  • Tissue specificity
    Expressed on monocytes and B-cells, and at lower levels on dendritic cells. Detected at low levels in natural killer (NK) cells.
  • Sequence similarities
    Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
  • Domain
    Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Post-translational
    modifications
    Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD85 antigen-like family member D antibody
    • CD85d antibody
    • CD85d antigen antibody
    • ILT 4 antibody
    • ILT-4 antibody
    • ILT4 antibody
    • Immunoglobulin like transcript 4 antibody
    • Immunoglobulin-like transcript 4 antibody
    • Leukocyte immunoglobulin like receptor 2 antibody
    • Leukocyte immunoglobulin like receptor subfamily B member 2 antibody
    • Leukocyte immunoglobulin-like receptor 2 antibody
    • Leukocyte immunoglobulin-like receptor subfamily B member 2 antibody
    • Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 antibody
    • LILRA6 antibody
    • LILRB2 antibody
    • LIR 2 antibody
    • LIR-2 antibody
    • LIR2 antibody
    • LIRb antibody
    • LIRB2_HUMAN antibody
    • MIR 10 antibody
    • MIR-10 antibody
    • MIR10 antibody
    • Monocyte/macrophage immunoglobulin like receptor 10 antibody
    • Monocyte/macrophage immunoglobulin-like receptor 10 antibody
    see all

Images

  • Staining of normal Human peripheral blood cells with Rat IgM ? Isotype Control FITC (open histogram) or ab95819 (filled histogram). Cells in the monocyte gate were used for analysis.

References

ab95819 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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