Overview

  • Product nameAnti-LIN7C antibody
    See all LIN7C primary antibodies
  • Description
    Rabbit polyclonal to LIN7C
  • Tested applicationsSuitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within the N terminal amino acids 1-50 (AALGEPVRLE RDICRAIELL EKLQRSGEVP PQKLQALQRV LQSEFCNAVR) of Human LIN7C (NP_060832).

  • Positive control
    • HepG2 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab82646 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml.
WB Use a concentration of 1 µg/ml. Detects a band of approximately 22 kDa (predicted molecular weight: 22 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • RelevanceLIN7C plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. It forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. LIN7C ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. It is also required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
  • Cellular localizationCell membrane. Peripheral membrane protein. Basolateral cell membrane. Cell junction. Enriched in synaptosomes and at epithelial cell-cell junctions. Mainly basolateral in renal epithelial cells.
  • Database links
  • Alternative names
    • LIN 7 C antibody
    • Lin 7 homolog C (C. elegans) antibody
    • LIN 7 protein 3 antibody
    • LIN 7C antibody
    • LIN7 protein 3 antibody
    • MALS 3 antibody
    • MALS3 antibody
    • Mammalian lin seven protein 3 antibody
    • Protein lin 7 homolog C antibody
    • Veli 3 antibody
    • Veli 3 protein antibody
    • VELI3 antibody
    • Vertebrate lin 7 homolog 3 antibody
    see all

Anti-LIN7C antibody images

  • Anti-LIN7C antibody (ab82646) at 1 µg/ml (in 5% skim milk / PBS buffer) + HepG2 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 22 kDa
    Observed band size : 22 kDa
  • ab82646 at 5 µg/ml staining LIN7C in Human colon by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).
  • ab82646 at 5 µg/ml staining LIN7C in Human tonsil tissue by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).

References for Anti-LIN7C antibody (ab82646)

ab82646 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"