Quinoline derivative immunomodulator which has antitumor properties. Has therapeutic effects in several experimental animal models of autoimmune diseases. Inhibits angiogenesis in rats and apoptosis of T-cells in vivo. Reduces the secretion of TNF alpha.
Store at Room Temperature. The product can be stored for up to 12 months.
Soluble in 1.1eq. NaOH to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Abdul-Hai A et al. Effect of Linomide on adhesion molecules, TNF-alpha, nitrogen oxide, and cell adhesion. Int Immunopharmacol5:231-9 (2005).
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Hedlund G et al. Effects of Linomide on immune cells and cytokines inhibit autoimmune pathologies of the central and peripheral nervous system. Int Immunopharmacol1:1123-30 (2001).
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