Overview

  • Product name
    Linomide
  • Description
    Immunomodulator with anti-angiogenic and antitumor properties
  • Alternative names
    • 1,2-Dihydro-4-hydroxy-N,N-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide
    • LS 2616
    • N-Phenylmethyl-1,2-dihydro-4-hydroxyl-1-methyl-2-oxo-quinoline-3-carboxamide
    • Roquinimex
  • Biological description

    Quinoline derivative immunomodulator which has antitumor properties. Has therapeutic effects in several experimental animal models of autoimmune diseases. Inhibits angiogenesis in rats and apoptosis of T-cells in vivo. Reduces the secretion of TNF alpha.

  • Purity
    > 97%

Properties

  • Chemical name
    1,2-Dihydro-4-hydroxy-N,N'-dimethyl-2-oxo-N'-phenyl-3-quinolinecarboxamide
  • Molecular weight
    308.33
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C18H16N2O3
  • CAS Number
    84088-42-6
  • Storage instructions
    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in 1.1eq. NaOH to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:
  • Xiao ZY  et al. Inhibitory effect of linomide on lipopolysaccharide-induced proinflammatory cytokine tumor necrosis factor-alpha production in RAW264.7 macrophages through suppression of NF-kappaB, p38, and JNK activation. Immunol Lett 114:81-5 (2007). Read more (PubMed: 17964662) »
  • Abdul-Hai A  et al. Effect of Linomide on adhesion molecules, TNF-alpha, nitrogen oxide, and cell adhesion. Int Immunopharmacol 5:231-9 (2005). Read more (PubMed: 15652754) »
  • Hedlund G  et al. Effects of Linomide on immune cells and cytokines inhibit autoimmune pathologies of the central and peripheral nervous system. Int Immunopharmacol 1:1123-30 (2001). Read more (PubMed: 11407306) »
  • Gonzalo JA  et al. Linomide inhibits programmed cell death of peripheral T cells in vivo. Eur J Immunol 24:48-52 (1994). Read more (PubMed: 8020570) »
  • Vukanovic J  et al. Antiangiogenic effects of the quinoline-3-carboxamide linomide. Cancer Res 53:1833-7 (1993). Read more (PubMed: 7682157) »
  • Ichikawa T  et al. The antitumor effects of the quinoline-3-carboxamide linomide on Dunning R-3327 rat prostatic cancers. Cancer Res 52:3022-8 (1992). Read more (PubMed: 1591718) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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