The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500. Detects a band of approximately 57 kDa.
FunctionHas phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin.
Tissue specificityHigh level of expression in the liver, placenta, lung, thyroid, kidney, testis and in the corpus luteum of the ovary. Expressed also in coronary artery endothelial cells, umbilical vein endothelial cells and in hepatocyte and osteosarcoma cell lines. Not detected in heart, brain and muscle.
Sequence similaritiesBelongs to the AB hydrolase superfamily. Lipase family. Contains 1 PLAT domain.
Human LIPG detected in transfected 293 lysates, using ab14797.
References for Anti-LIPG antibody (ab14797)
This product has been referenced in:
Singaraja RR et al. The impact of partial and complete loss-of-function mutations in endothelial lipase on high-density lipoprotein levels and functionality in humans. Circ Cardiovasc Genet6:54-62 (2013).
Read more (PubMed: 23243195) »
Kivelä AM et al. Sulforaphane inhibits endothelial lipase expression through NF-?B in endothelial cells. Atherosclerosis213:122-8 (2010).
Read more (PubMed: 20688330) »