Overview

  • Product nameAnti-LIPI antibody
    See all LIPI primary antibodies
  • Description
    Rabbit polyclonal to LIPI
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rabbit, Pig
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 359-408 (YFVLSIIVPD KTMMDGSFSF KLLNQLGMIE EPRLYEKNKP FYKLQEVKIL) of Human LIPI (NP_945347).

  • Positive control
    • NCI-H226 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab106123 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 53 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionHydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).
  • Tissue specificityExpressed in testis. Expressed exclusively at the connecting piece of the sperm.
  • Involvement in diseaseDefects in LIPI may be a cause of susceptibility to familial hypertriglyceridemia (FHTR)[MIM:145750]. Familial hypertriglyceridemia is a common inherited disorder in which the concentration of very low density lipoprotein (VLDL) is elevated in the plasma. This leads to increased risk of heart disease, obesity, and pancreatitis.
  • Sequence similaritiesBelongs to the AB hydrolase superfamily. Lipase family.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationMembrane. May associate with lipid draft and Membrane. Secreted. May associate with lipid draft.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cancer/testis antigen 17 antibody
    • CT17 antibody
    • Lipase member I antibody
    • LIPI antibody
    • LIPI_HUMAN antibody
    • LPD lipase antibody
    • LPDL antibody
    • Membrane-associated phosphatidic acid-selective phospholipase A1-beta antibody
    • membrane-associated phospholipase A1 beta 7B+ antibody
    • membrane-associated phospholipase A1 beta deltaE2-3 antibody
    • membrane-associated phospholipase A1 beta deltaE5 antibody
    • membrane-associated phospholipase A1 beta deltaE6.1 antibody
    • membrane-associated phospholipase A1 beta deltaE7.2 antibody
    • membrane-associated phospholipase A1 beta deltaE8-9 antibody
    • membrane-associated phospholipase A1 beta fl antibody
    • mPA-PLA1 beta antibody
    • PLA1C antibody
    • PRED5 antibody
    see all

Anti-LIPI antibody images

  • Anti-LIPI antibody (ab106123) at 1 µg/ml + NCI-H226 cell lysate at 10 µg

    Predicted band size : 53 kDa

References for Anti-LIPI antibody (ab106123)

ab106123 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"