Overview

  • Product name
  • Description
    Rabbit polyclonal to Lipin 2
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide surrounding amino acid 871 of mouse Lipin 2

  • Positive control
    • Jurkat cell and Mouse tissue lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab63928 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 4 µg/ml. Detects a band of approximately 99 kDa (predicted molecular weight: 99 kDa).

Target

  • Function
    Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism.
  • Tissue specificity
    Expressed in liver, lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon.
  • Involvement in disease
    Defects in LPIN2 are the cause of Majeed syndrome (MAJEEDS) [MIM:609628]. An autosomal recessive syndrome characterized by chronic recurrent multifocal osteomyelitis that is of early onset with a lifelong course, congenital dyserythropoietic anemia that presents as hypochromic, microcytic anemia during the first year of life and ranges from mild to transfusion-dependent, and transient inflammatory dermatosis, often manifesting as Sweet syndrome (neutrophilic skin infiltration).
  • Sequence similarities
    Belongs to the lipin family.
  • Domain
    Contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif known to be essential for phosphatidate phosphatase activity.
    Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, a motif known to be a transcriptional binding motif.
  • Cellular localization
    Nucleus. Cytoplasm > cytosol. Endoplasmic reticulum membrane. Translocates to endoplasmic reticulum membrane with increasing levels of oleate.
  • Information by UniProt
  • Database links
  • Alternative names
    • KIAA0249 antibody
    • Lipin-2 antibody
    • Lipin2 antibody
    • LPIN 2 antibody
    • LPIN2 antibody
    • LPIN2_HUMAN antibody
    • OTTHUMP00000162242 antibody
    • Phosphatidate phosphatase LPIN2 antibody
    see all

Images

  • All lanes : Anti-Lipin 2 antibody (ab63928) at 0.5 µg/ml

    Lane 1 : Jurkat cell lysate
    Lane 2 : Mouse tissue lysate


    Predicted band size : 99 kDa
    Observed band size : 99 kDa

References

This product has been referenced in:
  • Cai K  et al. Silencing diacylglycerol kinase-theta expression reduces steroid hormone biosynthesis and cholesterol metabolism in human adrenocortical cells. Biochim Biophys Acta 1841:552-62 (2014). WB . Read more (PubMed: 24369117) »
  • Zhang C  et al. Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling. Proc Natl Acad Sci U S A 109:1667-72 (2012). WB ; Mouse . Read more (PubMed: 22307628) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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