Overview

  • Product nameAnti-Lipoic Acid antibody
  • Description
    Rabbit polyclonal to Lipoic Acid
  • SpecificityRecognizes native lipoic acid and lipoic acid covalently attached to proteins. It does not recognize lipoic acid modified by 4-HNE (4-hydroxy-2-noneal) and other lipid peroxidation products.
  • Tested applicationsSuitable for: WB, IHC-Fr, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with a broad range of species.
  • Immunogen

    Lipoic acid conjugated to KLH

Properties

Applications

Our Abpromise guarantee covers the use of ab58724 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
IHC-Fr
ELISA
IHC-P
  • Application notesELISA: 1/500 - 1/1000.
    IHC-Fr: 1/50 - 1/500.
    IHC-P: 1/50 - 1/500.
    WB: 1/1000 - 1/10000.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceLipoic acid is a sulfur-containing substance that is readily converted to and from its reduced form, dihydrolipoic acid. It acts as a coenzyme in reactions that occur in the Krebs cycle; specifically it is involved in the decarboxylation of pyruvate and some other alpha-keto acids. Protein-bound lipoic acids such as E2 subunits, a-ketoglutarate dehydrogenase, or pyruvate dehydrogenase have been shown to be highly susceptible to free radical-derived oxidative modification. Lipoic acid is able to deactivate both fat and water soluble free radicals and thereby protect both lipoproteins and membranes; no other anti-oxidant can do this. It has also shown great promise in the treatment of HIV and in diabetes.

    References for Anti-Lipoic Acid antibody (ab58724)

    This product has been referenced in:
    • Ajit Bolar N  et al. Mutation of the iron-sulfur cluster assembly gene IBA57 causes severe myopathy and encephalopathy. Hum Mol Genet 22:2590-602 (2013). WB . Read more (PubMed: 23462291) »
    • Liu X  et al. Structural insights into the N-terminal GIY-YIG endonuclease activity of Arabidopsis glutaredoxin AtGRXS16 in chloroplasts. Proc Natl Acad Sci U S A 110:9565-70 (2013). Read more (PubMed: 23690600) »

    See all 3 Publications for this product

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