Overview

  • Product name
    Anti-Lipoic Acid antibody
  • Description
    Rabbit polyclonal to Lipoic Acid
  • Specificity
    Recognizes native lipoic acid and lipoic acid covalently attached to proteins. It does not recognize lipoic acid modified by 4-HNE (4-hydroxy-2-noneal) and other lipid peroxidation products.
  • Tested applications
    Suitable for: WB, IHC-Fr, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with a broad range of species.
  • Immunogen

    Lipoic acid conjugated to KLH

Properties

Applications

Our Abpromise guarantee covers the use of ab58724 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
IHC-Fr
ELISA
IHC-P
  • Application notes
    ELISA: 1/500 - 1/1000.
    IHC-Fr: 1/50 - 1/500.
    IHC-P: 1/50 - 1/500.
    WB: 1/1000 - 1/10000.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Relevance
      Lipoic acid is a sulfur-containing substance that is readily converted to and from its reduced form, dihydrolipoic acid. It acts as a coenzyme in reactions that occur in the Krebs cycle; specifically it is involved in the decarboxylation of pyruvate and some other alpha-keto acids. Protein-bound lipoic acids such as E2 subunits, a-ketoglutarate dehydrogenase, or pyruvate dehydrogenase have been shown to be highly susceptible to free radical-derived oxidative modification. Lipoic acid is able to deactivate both fat and water soluble free radicals and thereby protect both lipoproteins and membranes; no other anti-oxidant can do this. It has also shown great promise in the treatment of HIV and in diabetes.

    References for Anti-Lipoic Acid antibody (ab58724)

    This product has been referenced in:
    • Lacroix M  et al. E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity. Proc Natl Acad Sci U S A 113:10998-1003 (2016). WB . Read more (PubMed: 27621446) »
    • Ahting U  et al. Clinical, biochemical, and genetic spectrum of seven patients with NFU1 deficiency. Front Genet 6:123 (2015). WB ; Human . Read more (PubMed: 25918518) »

    See all 6 Publications for this product

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