Anti-Lipoprotein a antibody [EPR6474] (ab125014)

Overview

  • Product nameAnti-Lipoprotein a antibody [EPR6474]
    See all Lipoprotein a primary antibodies
  • Description
    Rabbit monoclonal [EPR6474] to Lipoprotein a
  • Tested applicationsSuitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC/IF or IHC-P
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A synthetic peptide, corresponding to residues in Human Lipoprotein a.

  • Positive control
    • WB: Human plasma lysate.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated "PUR" on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab125014 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/10000 - 1/50000. Detects a band of approximately 501 kDa (predicted molecular weight: 501 kDa).
  • Application notesIs unsuitable for Flow Cyt,ICC/IF or IHC-P.
  • Target

    • RelevanceLipoprotein(a) (Lp(a)) is a lipoprotein subclass assembled in the blood from low density lipoprotein (LDL) molecules and apolipoprotein-a (apo-a). Lp(a) recruits inflammatory cells through interaction with Mac-1 integrin. High Lp(a) in blood is a risk factor for coronary heart disease, cerebrovascular disease, atherosclerosis, thrombosis, and stroke. Lp(a) concentrations may be affected by disease states, but are only moderately affected by diet, exercise and other environmental factors. Lipid-reducing drugs have no effect on Lp(a) concentration. High Lp(a) predicts risk of early atherosclerosis similar to high LDL, but in advanced atherosclerosis, Lp(a) is a risk factor independent of LDL, indicating a coagulant risk of plaque thrombosis. Apo(a) contains domains that are very similar to plasminogen (PLG). Lp(a) accumulates in the vessel wall and inhibits binding of PLG to the cell surface, reducing plasmin generation which increases clotting. This inhibition also promotes proliferation of smooth muscle cells. These unique features of Lp(a) suggest a role in the generation of clots and atherosclerosis.
    • Database links
    • Alternative names
      • AK38 antibody
      • Antiangiogenic AK38 protein antibody
      • apo(a) antibody
      • APOA antibody
      • apolipoprotein(a) antibody
      • LP antibody
      • lp(a) antibody
      • LPA antibody
      see all

    Anti-Lipoprotein a antibody [EPR6474] images

    • Anti-Lipoprotein a antibody [EPR6474] (ab125014) at 1/50000 dilution (purified) + Human plasma lysate at 10 µg

      Secondary
      HRP-conjugated goat anti-rabbit IgG (specific to the non-reduced form of IgG) at 1/1000 dilution

      Predicted band size : 501 kDa
      Observed band size : 501 kDa

      Blocking and dilution buffer: 5% NFDM /TBST.

      The observed bands are consistant with desciption in PMID:10703674, which should be N-terminal fragments.

    • Anti-Lipoprotein a antibody [EPR6474] (ab125014) at 1/20000 dilution (unpurified) + Human plasma lysate at 10 µg

      Secondary
      HRP-conjugated goat anti-rabbit IgG at 1/2000 dilution

      Predicted band size : 501 kDa
      Observed band size : 500 kDa (why is the actual band size different from the predicted?)

    References for Anti-Lipoprotein a antibody [EPR6474] (ab125014)

    ab125014 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab125014.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"