Overview

  • Product nameAnti-LITAF antibody [AT5C10]
    See all LITAF primary antibodies
  • Description
    Mouse monoclonal [AT5C10] to LITAF
  • Tested applicationsSuitable for: WB, Indirect ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length Human LITAF purified from E. coli, amino acids 1-161 (NP_004853)

  • Positive control
    • HeLa cell lysate.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab89597 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2000 - 1/3000. Predicted molecular weight: 17 kDa.
Indirect ELISA Use at an assay dependent dilution.

Target

  • FunctionProbable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF-alpha) gene expression.
  • Tissue specificityUbiquitously and abundantly expressed. Expressed predominantly in the placenta, peripheral blood leukocytes, lymph nodes and spleen.
  • Involvement in diseaseDefects in LITAF are the cause of Charcot-Marie-Tooth disease type 1C (CMT1C) [MIM:601098]. CMT1C is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT1 group are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet.
    Note=Defects in LITAF may be involved in extramammary Paget disease (EMPD) carcinogenesis. EMPD is a cancerous disease representing about 8% of all malignant skin cancers; it usually appears in the anogenital area and can be fatal by metastasizing to internal organs when left untreated for a long time. The clinical features are usually those of eczematous eruptions with weeping and crust formation.
  • DomainThe WW-binding motif mediates interaction with WWOX and, probably NEDD4.
  • Cellular localizationLysosome membrane. Associated with membranes of lysosomes.
  • Information by UniProt
  • Database links
  • Alternative names
    • Lipopolysaccharide induced TNF alpha factor antibody
    • CMT1C antibody
    • FLJ38636 antibody
    • Lipopolysaccharide induced TNF alpha factor antibody
    • Lipopolysaccharide induced TNF factor antibody
    • Lipopolysaccharide induced tumor necrosis factor alpha factor antibody
    • Lipopolysaccharide-induced tumor necrosis factor-alpha factor antibody
    • LITAF antibody
    • LITAF_HUMAN antibody
    • LPS induced TNF alpha factor antibody
    • LPS-induced TNF-alpha factor antibody
    • MGC116698 antibody
    • MGC116700 antibody
    • MGC116701 antibody
    • MGC125274 antibody
    • MGC125275 antibody
    • MGC125276 antibody
    • p53 induced gene 7 protein antibody
    • p53-induced gene 7 protein antibody
    • PIG 7 antibody
    • PIG7 antibody
    • SIMPLE antibody
    • Small integral membrane protein of lysosome/late endosome antibody
    • TP53I7 antibody
    • Tumor protein p53 inducible protein 7 antibody
    see all

Anti-LITAF antibody [AT5C10] images

  • Anti-LITAF antibody [AT5C10] (ab89597) at 1/2000 dilution + HeLa cell lysate at 20 µg

    Secondary
    goat anti-mouse HRP
    Developed using the ECL technique

    Predicted band size : 17 kDa
    Observed band size : 23 kDa (why is the actual band size different from the predicted?)

References for Anti-LITAF antibody [AT5C10] (ab89597)

ab89597 has not yet been referenced specifically in any publications.

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