ab94083 is a 293T cell transfected lysate in which Human liver Arginase has been transiently over-expressed using a pCMV-ARG1 Full length plasmid. The lysate is provided in 1 x Sample Buffer. Note: For more detailed how the transfected lysate was prepared view preparation notes.
Pathway: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.
Disease: Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:207800]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.
Similarity: Belongs to the arginase family.