Overview

  • Product nameAnti-Livin antibody
    See all Livin primary antibodies
  • Description
    Rabbit polyclonal to Livin
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    GPQPSHWAAGDGPTQERC

    , corresponding to N terminal amino acids 13-30 of Human Livin.

  • Positive control
    • Jurkat or Raji cell lysates. Most melanoma cell lines express high levels of ML-IAP.

Properties

Applications

Our Abpromise guarantee covers the use of ab14558 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/250 - 1/500. Predicted molecular weight: 33 kDa.

Target

  • FunctionProtects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits caspase-3 and proteolytic activation of pro-caspase-9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis.
  • Tissue specificityIsoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes.
  • Sequence similaritiesBelongs to the IAP family.
    Contains 1 BIR repeat.
    Contains 1 RING-type zinc finger.
  • Cellular localizationNucleus. Cytoplasm. Nuclear, and in a filamentous pattern throughout the cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • Baculoviral IAP repeat containing 7 antibody
    • Baculoviral IAP repeat containing protein 7 antibody
    • Baculoviral IAP repeat-containing protein 7 antibody
    • BIRC 7 antibody
    • birc7 antibody
    • BIRC7_HUMAN antibody
    • KIAP antibody
    • Kidney inhibitor of apoptosis protein antibody
    • Livin antibody
    • Livin inhibitor of apotosis antibody
    • Melanoma inhibitor of apoptosis protein antibody
    • ML IAP antibody
    • ML-IAP antibody
    • MLIAP antibody
    • RING finger protein 50 antibody
    • RNF 50 antibody
    • RNF50 antibody
    see all

References for Anti-Livin antibody (ab14558)

ab14558 has not yet been referenced specifically in any publications.

Product Wall

Thank you for bringing this matter to my attention. The immunogen appears to be incorrect. The correct immunogen sequence is listed below: 13-30, GPQPSHWAAGDGPTQERC of the Livin protein. It is good to notice that that immunogen sequence is found...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"