Overview

  • Product name
  • Description
    Rabbit polyclonal to Livin
  • Specificity
    Detects both the alpha and beta (short and long) isoforms of Livin.
  • Tested applications
    Suitable for: ICC/IF, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    CRAPVRSRVRTFLS

    , corresponding to amino acids 264 - 280 (short form) or 281 - 298 (long form) of Human Livin.

  • Positive control
    • WB: Raji cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab5393 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF
WB
  • Application notes
    WB: Use at a concentration of 2 - 4 µg/ml. Detects bands of approximately 30 kDa (possibly short form) + 33 kDa (long form).

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits caspase-3 and proteolytic activation of pro-caspase-9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis.
    • Tissue specificity
      Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes.
    • Sequence similarities
      Belongs to the IAP family.
      Contains 1 BIR repeat.
      Contains 1 RING-type zinc finger.
    • Cellular localization
      Nucleus. Cytoplasm. Nuclear, and in a filamentous pattern throughout the cytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • Baculoviral IAP repeat containing 7 antibody
      • Baculoviral IAP repeat containing protein 7 antibody
      • Baculoviral IAP repeat-containing protein 7 antibody
      • BIRC 7 antibody
      • birc7 antibody
      • BIRC7_HUMAN antibody
      • KIAP antibody
      • Kidney inhibitor of apoptosis protein antibody
      • Livin antibody
      • Livin inhibitor of apotosis antibody
      • Melanoma inhibitor of apoptosis protein antibody
      • ML IAP antibody
      • ML-IAP antibody
      • MLIAP antibody
      • RING finger protein 50 antibody
      • RNF 50 antibody
      • RNF50 antibody
      see all

    Anti-Livin antibody images

    • Anti-Livin antibody (ab5393) at 4 µg/ml + Human Raji cell lysate

      Observed band size : 33 kDa (why is the actual band size different from the predicted?)
    • Immunofluorescence of Livin in Human Small Intestine cells using ab5393 at 20 ug/ml.

    References for Anti-Livin antibody (ab5393)

    ab5393 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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