Overview

Description

  • NatureSynthetic

Specifications

Our Abpromise guarantee covers the use of ab6234 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • FormLiquid
  • Additional notesStable for one year.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

General Info

  • Alternative names
    • Baculoviral IAP repeat containing 7
    • Baculoviral IAP repeat containing protein 7
    • Baculoviral IAP repeat-containing protein 7
    • BIRC 7
    • birc7
    • BIRC7_HUMAN
    • KIAP
    • Kidney inhibitor of apoptosis protein
    • Livin
    • Livin inhibitor of apotosis
    • Melanoma inhibitor of apoptosis protein
    • ML IAP
    • ML-IAP
    • MLIAP
    • RING finger protein 50
    • RNF 50
    • RNF50
    see all
  • FunctionProtects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits caspase-3 and proteolytic activation of pro-caspase-9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis.
  • Tissue specificityIsoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes.
  • Sequence similaritiesBelongs to the IAP family.
    Contains 1 BIR repeat.
    Contains 1 RING-type zinc finger.
  • Cellular localizationNucleus. Cytoplasm. Nuclear, and in a filamentous pattern throughout the cytoplasm.
  • Information by UniProt

References for Livin peptide (ab6234)

This product has been referenced in:
  • Lin H  et al. Differential Expression of Livin, Caspase-3, and Second Mitochondria-Derived Activator of Caspases in Chronic Rhinosinusitis with Nasal Polyps. Otolaryngol Head Neck Surg N/A:N/A (2014). Read more (PubMed: 25238746) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"