Overview

  • Product nameAnti-LLGL1 antibody [4D11] (FITC)
    See all LLGL1 primary antibodies
  • Description
    Rat monoclonal [4D11] to LLGL1 (FITC)
  • ConjugationFITC. Ex: 493nm, Em: 528nm
  • Tested applicationsSuitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Large granular lymphocytes (LGL) enriched from C57BL/6N mouse liver

  • Positive control
    • Mouse splenocytes.

Properties

Applications

Our Abpromise guarantee covers the use of ab95802 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use 0.125-0.25µg for 105-8 cells. Perform staining in a final volume of 100 µl.



ab18446-Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

Target

  • FunctionCortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells.
  • Tissue specificityExpressed in brain, kidney, and muscle but is barely seen in heart and placenta. Down-regulated or lost in all cell lines and in most of the tumor samples analyzed. Loss was associated with advanced stage of the disease.
  • Sequence similaritiesBelongs to the WD repeat L(2)GL family.
    Contains 14 WD repeats.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity). Phosphorylated at least at Ser-663 by PRKCI.
  • Cellular localizationCytoplasm > cytoskeleton. Localized to the lateral membrane during the polarization and formation cell-cell contacts.
  • Information by UniProt
  • Database links
  • Alternative names
    • DLG4 antibody
    • DLG4, formerly antibody
    • Hugl 1 antibody
    • HUGL antibody
    • Hugl-1 antibody
    • HUGL1 antibody
    • Human homolog to the D-lgl gene protein antibody
    • L2GL1_HUMAN antibody
    • Lethal giant larvae homolog 1 (Drosophila) antibody
    • Lethal giant larvae homolog 1 antibody
    • Lethal(2) giant larvae protein homolog 1 antibody
    • LLGL antibody
    • Llgl1 antibody
    • Ly 49G2 antibody
    • Ly49G2 antibody
    • Mgl1 antibody
    • Mlgl antibody
    see all

Anti-LLGL1 antibody [4D11] (FITC) images

  • Staining of C57BL/6 splenocytes with Anti-Mouse CD49b (Integrin alpha2) PE and 0.125 µg of Rat IgG2a k Isotype Control FITC (left) or 0.125 µg of ab95802 (right). Total viable cells were used for analysis.

References for Anti-LLGL1 antibody [4D11] (FITC) (ab95802)

This product has been referenced in:
  • Ortaldo JR  et al. The Ly-49 family: regulation of cytotoxicity and cytokine production in murine CD3+ cells. J Immunol 160:1158-65 (1998). Read more (PubMed: 9570529) »
  • Mason LH  et al. Cloning and functional characteristics of murine large granular lymphocyte-1: a member of the Ly-49 gene family (Ly-49G2) J Exp Med 182:293-303 (1995). Read more (PubMed: 7629495) »

See all 3 Publications for this product

Product Wall

There are currently no Abreviews or Questions for ab95802.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"