Overview

  • Product name
  • Description
    Rabbit polyclonal to LLGL2
  • Specificity
    Reacts specifically with human 113 kDa protein.
  • Tested applications
    Suitable for: WB, IHC-Frmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide derived from N terminal domain of human LLGL2 protein

Properties

Applications

Our Abpromise guarantee covers the use of ab73304 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Predicted molecular weight: 113 kDa.
IHC-Fr Use at an assay dependent concentration.

Target

  • Function
    Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity.
  • Sequence similarities
    Belongs to the WD repeat L(2)GL family.
    Contains 14 WD repeats.
  • Post-translational
    modifications
    Phosphorylated at Ser-653 by PRKCI. Phosphorylation is enhanced during cell polarization induced by calcium. Phosphorylation may occur during the cell-cell contact-induced cell polarization and may contribute to the segregation of LLGL2 from the PRKCI/aPKC and PARD6B/Par-6 complex.
  • Cellular localization
    Cytoplasm. Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells. Found in the lateral region of polarized epithelial cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • HGL antibody
    • Human giant larvae homolog antibody
    • L2GL2 antibody
    • L2GL2_HUMAN antibody
    • Lethal 2 giant larvae protein homolog 2 antibody
    • Lethal giant larvae homolog 2 antibody
    • Lethal(2) giant larvae protein homolog 2 antibody
    • LGL2 antibody
    • LLGL2 antibody
    see all

References

ab73304 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab73304.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up