Overview

  • Product nameAnti-LMBRD1 antibody
    See all LMBRD1 primary antibodies
  • Description
    Rabbit polyclonal to LMBRD1
  • SpecificityLMBRD1 antibody is predicted to not cross-react with other LMBRD1 family members.
  • Tested applicationsSuitable for: ICC/IF, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    An 18 amino acid peptide from the C-terminus of Human LMBRD1 (NP_060838)

  • Positive control
    • Human Brain Tissue Lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab105419 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 61 kDa.
IHC-P Use at an assay dependent concentration.

Target

  • FunctionProbable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV).
  • Tissue specificityIsoform 3 is expressed in liver.
  • Involvement in diseaseDefects in LMBRD1 are the cause of methylmalonic aciduria and homocystinuria type cblF (MMAFHC) [MIM:277380]; also known as homocystinuria-megaloblastic anemia complementation type F. MMAFHC is a disorder of cobalamin metabolism characterized by decreased levels of the coenzymes adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl). It is due to accumulation of free cobalamin in lysosomes, thus hindering its conversion to cofactors. Clinical features include developmental delay, stomatitis, glossitis, seizures and methylmalonic aciduria responsive to vitamin B12.
  • Sequence similaritiesBelongs to the LIMR family. LMBRD1 subfamily.
  • Post-translational
    modifications
    N-glycosylated.
  • Cellular localizationLysosome membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • HDAg-L-interacting protein NESI antibody
    • LMBD1_HUMAN antibody
    • LMBR1 domain-containing protein 1 antibody
    • lmbrd1 antibody
    • Nuclear export signal-interacting protein antibody
    • Probable lysosomal cobalamin transporter antibody
    see all

Anti-LMBRD1 antibody images

  • Immunofluorescence of LMBRD1 in Human brain tissue with ab105419 at 20 ug/mL.
  • Immunohistochemistry of LMBRD1 in Human brain tissue with ab105419 at 2.5 μg/mL.

  • Anti-LMBRD1 antibody (ab105419) at 1 µg/ml + Human brain tissue lysate at 15 µg

    Predicted band size : 61 kDa

References for Anti-LMBRD1 antibody (ab105419)

ab105419 has not yet been referenced specifically in any publications.

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