Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T cells signaling pathway.
Expressed in the heart (at protein level). Expressed in many tissues with highest abundance in skeletal muscle.
Contains 2 LIM zinc-binding domains. Contains 1 PET domain.
The LIM zinc-binding domains and the Cys-rich region mediate interaction with GATA6.
Cytoplasm. Nucleus. May shuttle between the cytoplasm and the nucleus.
Western blot analysis on immunoprecipitation pellet from (1) Human skeletal muscle lysate or (2) 1XPBS (negative control) using ab179454, and HRP-conjugated anti-rabbit IgG preferentially detecting the non-reduced form of rabbit IgG.