Overview

  • Product name
  • Description
    Rabbit polyclonal to LOC285498
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-202 of Human LOC285498 (UniProt: Q495C1).

  • Positive control
    • PC3 whole cell lysate; Human U87 xenograft tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab154021 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 33 kDa.
IHC-P 1/100 - 1/1000.

Target

  • Function
    Key regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May act as a SUMO E3 ligase that mediates sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement.
  • Pathway
    Protein modification; protein sumoylation.
  • Sequence similarities
    Contains 1 RING-type zinc finger.
  • Cellular localization
    Nucleus. Chromosome. Associates to the synaptonemal complex. Localizes to a minority of double-strand breaks (DSBs) sites. Marks crossover sites during midpachynema.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ38841 antibody
    • Hypothetical protein LOC285498 antibody
    • OTTHUMP00000147525 antibody
    • Probable E3 SUMO-protein ligase RNF212 antibody
    • RING finger protein 212 antibody
    • RN212_HUMAN antibody
    • RNF 212 antibody
    • RNF212 antibody
    • ZHP3 antibody
    • ZHP3, C. elegans, homolog of antibody
    • ZIP3-related protein antibody
    see all

Images

  • Anti-LOC285498 antibody (ab154021) at 1/1000 dilution + PC3 whole cell lysate at 30 µg

    Predicted band size: 33 kDa



    12% SDS PAGE
  • Immunohistochemical analysis of paraffin-embedded Human U87 xenograft tissue labeling LOC285498 with ab154021 at 1/500 dilution.

References

ab154021 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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