Overview

  • Product nameAnti-LONP1 antibody
    See all LONP1 primary antibodies
  • Description
    Rabbit polyclonal to LONP1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-959 of Human LONP1 (NP_004784.2).

  • Positive control
    • Human kidney, Mouse kidney, HepG2, transfected 293T cell line

Properties

Applications

Our Abpromise guarantee covers the use of ab103809 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 106 kDa.

Target

  • FunctionATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein.
  • Tissue specificityDuodenum, heart, lung and liver, but not thymus.
  • Involvement in diseaseCODAS syndrome
  • Sequence similaritiesBelongs to the peptidase S16 family.
    Contains 1 Lon domain.
  • Cellular localizationMitochondrion matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • hLON antibody
    • hLON ATP dependent protease antibody
    • LON antibody
    • lon peptidase 1, mitochondrial antibody
    • LON protease antibody
    • Lon protease homolog antibody
    • Lon protease like protein antibody
    • Lon protease-like protein antibody
    • LONHs antibody
    • LONM_HUMAN antibody
    • LONP antibody
    • Lonp1 antibody
    • MGC1498 antibody
    • mitochondrial antibody
    • Mitochondrial ATP dependent protease Lon antibody
    • Mitochondrial ATP-dependent protease Lon antibody
    • Mitochondrial lon peptidase 1 antibody
    • PIM1 antibody
    • Protease serine 15 antibody
    • PRSS15 antibody
    • Serine protease 15 antibody
    see all

Anti-LONP1 antibody images

  • Anti-LONP1 antibody (ab103809) at 5 µg/ml + Human kidney tissue lysate at 50 µg

    Predicted band size : 106 kDa
  • Anti-LONP1 antibody (ab103809) at 5 µg/ml + Mouse kidney tissue lysate at 50 µg

    Predicted band size : 106 kDa
  • Anti-LONP1 antibody (ab103809) at 5 µg/ml + HepG2 cell lysate at 50 µg

    Predicted band size : 106 kDa
  • All lanes : Anti-LONP1 antibody (ab103809) at 5 µg/ml

    Lane 1 : LONP1 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 106 kDa

References for Anti-LONP1 antibody (ab103809)

This product has been referenced in:
  • Goo HG  et al. HtrA2/Omi influences the stability of LON protease 1 and prohibitin, proteins involved in mitochondrial homeostasis. Exp Cell Res 328:456-65 (2014). Read more (PubMed: 25094062) »
  • Padrão AI  et al. Bladder cancer-induced skeletal muscle wasting: disclosing the role of mitochondria plasticity. Int J Biochem Cell Biol 45:1399-409 (2013). Read more (PubMed: 23608519) »

See all 2 Publications for this product

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