Overview

  • Product name
    Loperamide hydrochloride
  • Description
    Selective μ opioid receptor agonist
  • Biological description
    Peripheral selective μ opioid receptor agonist. Ki values are 3, 48 and 1156 nM for opioid receptor subtypes μ, δ and κ, respectively. High doses allow central μ receptor activation. Antidiarrheal, antipruritic and antihyperalgesic agent.
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • di Bosco AM  et al. Binding site of loperamide: automated docking of loperamide in human mu- and delta-opioid receptors. Chem Biol Drug Des 71:328-35 (2008). Read more (PubMed: 18284554) »
  • DeHaven-Hudkins DL  et al. Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity. J Pharmacol Exp Ther 289:494-502 (1999). Read more (PubMed: 10087042) »
  • Banerjee AK  et al. Acute diarrhoeal disease in rabbit: bacteriological diagnosis and efficacy of oral rehydration in combination with loperamide hydrochloride. Lab Anim 21:314-7 (1987). Read more (PubMed: 3695388) »
  • Mackerer CR  et al. Loperamide binding to opiate receptor sites of brain and myenteric plexus. J Pharmacol Exp Ther 199:131-40 (1976). Read more (PubMed: 10422) »

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