Overview

  • Product name
  • Description
    Mouse polyclonal to Loricrin
  • Host species
    Mouse
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein, corresponding to amino acids 1-316 of Human Loricrin (AAH34690.1).

  • Positive control
    • Loricrin transfected 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab168310 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 26 kDa.

Target

  • Function
    Major keratinocyte cell envelope protein.
  • Involvement in disease
    Defects in LOR are a cause of progressive symmetric erythrokeratodermia (PSEK) [MIM:133200]. Erythrokeratodermas are a group of disorders characterized by widespread erythematous plaques, either stationary or migratory, associated with features that include palmoplantar keratoderma. PSEK is characterized by erythematous and hyperkeratotic plaques.
    Defects in LOR are the cause of Vohwinkel syndrome with ichthyosis (VSI) [MIM:604117]; also known as loricrin keratoderma (LK) or mutilating keratoderma with ichthyosis. VSI is an ichthyotic variant of Vohwinkel syndrome (VS) characterized by progressive symmetric erythrokeratoderma or congenital ichthyosiform erythroderma born as a collodion baby. Common clinical features include hyperkeratosis of the palms and soles with digital constriction.
  • Post-translational
    modifications
    Substrate of transglutaminases. Some glutamines and lysines are cross-linked to other loricrin molecules and to SPRRs proteins.
    Contains inter- or intramolecular disulfide-bonds.
  • Cellular localization
    Cytoplasm. Nucleus > nucleoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • LOR antibody
    • LOR protein antibody
    • LORI_HUMAN antibody
    • Loricrin antibody
    • LRN antibody
    • MGC111513 antibody
    • OTTHUMP00000015823 antibody
    see all

Images

  • All lanes : Anti-Loricrin antibody (ab168310) at 1 µg/ml

    Lane 1 : Loricrin transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 15 µl per lane.

    Secondary
    All lanes : Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

    Developed using the ECL technique.

    Predicted band size: 26 kDa

References

ab168310 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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