Selective non-peptide angiotensin II AT1 receptor antagonist
Biological descriptionSelective non-peptide angiotensin II type 1 (AT1)receptor antagonist (Ki = 10 nM). Blocks classical actions of angiotensin II (ab120183). Displays antihypertensive action and downregulates TFG-β regulation. Active in vivo.
Chemical name2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol potassium salt
Storage instructionsStore at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Habashi JP et al. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science312:117-21 (2006).
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Guo ZX & Qiu MC [Losartan downregulates the expression of transforming growth factor beta type I and type II receptors in kidney of diabetic rat]. Zhonghua Nei Ke Za Zhi42:403-8 (2003).
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García-Sáinz JA et al. Characterization of the AT1 angiotensin II receptor expressed in guinea pig liver. J Endocrinol154:133-8 (1997).
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Ji H et al. Differential structural requirements for specific binding of nonpeptide and peptide antagonists to the AT1 angiotensin receptor. Identification of amino acid residues that determine binding of the antihypertensive drug losartan. J Biol Chem269:16533-6 (1994).
Read more (PubMed: 8206967) »