Biological description5-HT7 agonist. Selective over D2, 5-HT1A and 5-HT2A receptors (Ki values are 0.13, 224, 60.9 and >1000 nM, respectively). Shows pro-nociceptive effect.
Chemical name4-(1,1'-Biphenyl)-2-yl-N-(1,2,3,4-tetrahydro-1-naphthalenyl)-1-piperazinehexanamide hydrochloride
Storage instructionsStore at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Leopoldo M et al. Serotonin 5-HT7 receptor agents: Structure-activity relationships and potential therapeutic applications in central nervous system disorders. Pharmacol Ther129:120-48 (2011).
Read more (PubMed: 20923682) »
Godínez-Chaparro B et al. Role of peripheral 5-HT(4), 5-HT(6), and 5-HT(7) receptors in development and maintenance of secondary mechanical allodynia and hyperalgesia. Pain152:687-97 (2011).
Read more (PubMed: 21239110) »
Leopoldo M et al. Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2. J Med Chem50:4214-21 (2007).
Read more (PubMed: 17649988) »
Stern CD et al. Segmental lineage restrictions in the chick embryo spinal cord depend on the adjacent somites. Development113:239-44 (1991).
Read more (PubMed: 1764998) »