Recombinant
RabMAb

Anti-LPP antibody [EPR6478] (ab126608)

Overview

  • Product name
    Anti-LPP antibody [EPR6478]
    See all LPP primary antibodies
  • Description
    Rabbit monoclonal [EPR6478] to LPP
  • Tested applications
    Suitable for: WB, IHC-P, ICC/IFmore details
    Unsuitable for: Flow Cyt or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) corresponding to Human LPP aa 1-100 (N terminal).

  • Positive control
    • Caco 2, HeLa, NIH 3T3 cell lysates; Human breast and kidney tissues.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

Properties

Applications

Our Abpromise guarantee covers the use of ab126608 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/10000 - 1/50000. Detects a band of approximately 75 kDa (predicted molecular weight: 66 kDa).
IHC-P 1/250 - 1/500.
ICC/IF 1/100 - 1/250.
  • Application notes
    Is unsuitable for Flow Cyt or IP.
  • Target

    • Function
      May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.
    • Tissue specificity
      Expressed in a wide variety of tissues but no or very low expression in brain and peripheral leukocytes.
    • Involvement in disease
      Note=A chromosomal aberration involving LPP is associated with a subclass of benign mesenchymal tumors known as lipomas. Translocation t(3;12)(q27-q28;q13-q15) with HMGA2 is shown in lipomas.
      Note=A chromosomal aberration involving LPP is associated with pulmonary chondroid hamartomas. Translocation t(3;12)(q27-q28;q14-q15) with HMGA2 is detected in pulmonary chondroid hamartomas.
      Note=A chromosomal aberration involving LPP is associated with parosteal lipomas. Translocation t(3;12)(q28;q14) with HMGA2 is also shown in one parosteal lipoma.
      Note=A chromosomal aberration involving LPP is associated with acute monoblastic leukemia. Translocation t(3;11)(q28;q23) with MLL is associated with acute monoblastic leukemia.
    • Sequence similarities
      Belongs to the zyxin/ajuba family.
      Contains 3 LIM zinc-binding domains.
    • Cellular localization
      Nucleus. Cytoplasm. Cell junction. Cell membrane. Found in the nucleus, in the cytoplasm and at cell adhesion sites. Shuttles between the cytoplasm and the nucleus. It has been found in sites of cell adhesion such as cell-to-cell contact and focal adhesion which are membrane attachment sites of cells to the extracellular matrix. Mainly nuclear when fused with HMGA2/HMGIC and MLL.
    • Information by UniProt
    • Database links
    • Alternative names
      • DKFZp779O0231 antibody
      • FLJ30652 antibody
      • FLJ41512 antibody
      • LIM domain containing preferred translocation partner in lipoma antibody
      • LIM domain-containing preferred translocation partner in lipoma antibody
      • LIM protein antibody
      • Lipoma preferred partner antibody
      • Lipoma-preferred partner antibody
      • lpp antibody
      • LPP_HUMAN antibody
      see all

    Images

    • All lanes : Anti-LPP antibody [EPR6478] (ab126608) at 1/10000 dilution

      Lane 1 : Caco 2 cell lysate
      Lane 2 : HeLa cell lysate
      Lane 3 : NIH 3T3 cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      Goat anti-Rabbit HRP at 1/2000 dilution

      Predicted band size : 66 kDa
    • ab122608 at 1/250 staining LPP in paraffin embedded Human breast tissue by immunohistochemistry.
    • ab122608 at 1/250 staining LPP in paraffin embedded Human kidney tissue by immunohistochemistry.
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    References

    ab126608 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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