Overview

  • Product name
    Anti-LRFN1 antibody
  • Description
    Rabbit polyclonal to LRFN1
  • Host species
    Rabbit
  • Tested applications
    Suitable for: ICC/IF, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    18 amino acid peptide near the C terminus of Human LRFN1 (Q9P244).

  • Positive control
    • Human brain lysate, Mouse brain tissue

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at 4°C (stable for up to 12 months).
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab106365 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 82 kDa.
IHC-P Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval via the microwave method before commencing with IHC staining protocol.

Target

  • Function
    Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1.
  • Sequence similarities
    Belongs to the LRFN family.
    Contains 1 fibronectin type-III domain.
    Contains 1 Ig-like (immunoglobulin-like) domain.
    Contains 7 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 LRRNT domain.
  • Domain
    The PDZ-binding motif is required for neurite outgrowth promotion and for DLG1-, DLG3- and DLG4-binding.
  • Post-translational
    modifications
    Glycosylated.
  • Cellular localization
    Membrane. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Detected in excitatory, but not inhibitory, synaptic plasma membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • KIAA1484 antibody
    • Leucine rich repeat and fibronectin type III domain containing 1 antibody
    • Leucine rich repeat and fibronectin type III domain containing protein 1 antibody
    • Leucine-rich repeat and fibronectin type III domain-containing protein 1 antibody
    • LRFN 1 antibody
    • lrfn1 antibody
    • LRFN1_HUMAN antibody
    • SALM 2 antibody
    • SALM2 antibody
    • Synaptic adhesion like molecule 2 antibody
    • Synaptic adhesion-like molecule 2 antibody
    see all

Images

  • Immunofluorescence of LRFN1 in mouse brain tissue with ab106365 at 20 ug/mL.

  • Lane 1 : Anti-LRFN1 antibody (ab106365) at 1 µg/ml
    Lane 2 : Anti-LRFN1 antibody (ab106365) at 2 µg/ml

    All lanes : Human brain lysate

    Lysates/proteins at 15 µg per lane.

    Predicted band size: 82 kDa

  • ab106365 at 2.5 µg/ml staining LRFN1 in Mouse brain tissue by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.

References

ab106365 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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