Overview

  • Product nameAnti-LRIG1 antibody
    See all LRIG1 primary antibodies
  • Description
    Chicken polyclonal to LRIG1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to part of the cytoplasmic tail (C-terminal part).

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: PBS, pH 8
  • Concentration information loading...
  • PurityIgY fraction
  • ClonalityPolyclonal
  • IsotypeIgY
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab58853 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1 µg/ml, performed on lysates from over-expressing cells. Predicted molecular weight: 120 kDa.

    LRIG1 protein migrates during denaturing polyacrylamide gel electrophoresis under reducing conditions as two species with apparent molecular weights of 143kDa and 134kDa, and as two fragments corresponding to an N-terminal 111kDa species and a C-terminal 32kDa species. Under non-reducing conditions, both apparent monomers and apparent higher molecular weight complexes were evident.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionAct as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.
    • Tissue specificityWidely expressed.
    • Sequence similaritiesContains 3 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 15 LRR (leucine-rich) repeats.
      Contains 1 LRRCT domain.
      Contains 1 LRRNT domain.
    • DomainThe LRRs and the Ig-domains are each sufficient for EGFR/ERBB1 binding. This interaction is abolished only when these two domains are deleted.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • Leucine rich repeat protein antibody
      • Leucine rich repeat protein LRIG1 antibody
      • leucine rich repeats and immunoglobulin like domains 1 antibody
      • Leucine-rich repeats and immunoglobulin-like domains protein 1 antibody
      • leucine-rich repeats- and immunoglobulin-like domains-cotnaining protein 1 antibody
      • LIG 1 antibody
      • LIG-1 antibody
      • LIG1 antibody
      • Lrig1 antibody
      • LRIG1_HUMAN antibody
      • Ortholog of mouse integral membrane glycoprotein LIG 1 antibody
      see all

    References for Anti-LRIG1 antibody (ab58853)

    ab58853 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"