Validated using a knockout cell line

Anti-LRP1 antibody [EPR3724] (ab92544)

Publishing research using ab92544? Please let us know so that we can cite the reference in this datasheet.

ab92544 has been referenced in 23 publications.

  • Bian Z  et al. Cd47-Sirpa interaction and IL-10 constrain inflammation-induced macrophage phagocytosis of healthy self-cells. Proc Natl Acad Sci U S A 113:E5434-43 (2016). PubMed: 27578867
  • Chen Y  et al. HIV-1 Tat Regulates Occludin and Aß Transfer Receptor Expression in Brain Endothelial Cells via Rho/ROCK Signaling Pathway. Oxid Med Cell Longev 2016:4196572 (2016). PubMed: 27563375
  • Wang X  et al. Improvement of Electroacupuncture on APP/PS1 Transgenic Mice in Spatial Learning and Memory Probably due to Expression of Aß and LRP1 in Hippocampus. Evid Based Complement Alternat Med 2016:7603975 (2016). WB ; Mouse . PubMed: 27829865
  • Kim JA  et al. Presumed LRP1-targeting transport peptide delivers ß-secretase inhibitor to neurons in vitro with limited efficiency. Sci Rep 6:34297 (2016). PubMed: 27682851
  • Leca J  et al. Cancer-associated fibroblast-derived annexin A6+ extracellular vesicles support pancreatic cancer aggressiveness. J Clin Invest 126:4140-4156 (2016). WB, IP, IHC-P, ICC/IF ; Mouse, Human . PubMed: 27701147
  • Chuang TY  et al. LRP1 expression in microglia is protective during CNS autoimmunity. Acta Neuropathol Commun 4:68 (2016). ICC/IF ; Human . PubMed: 27400748
  • Alata W  et al. Human apolipoprotein E ?4 expression impairs cerebral vascularization and blood-brain barrier function in mice. J Cereb Blood Flow Metab 35:86-94 (2015). PubMed: 25335802
  • Samouillan V  et al. Cardiomyocyte intracellular cholesteryl ester accumulation promotes tropoelastin physical alteration and degradation: Role of LRP1 and cathepsin S. Int J Biochem Cell Biol 55:209-19 (2014). PubMed: 25218173
  • Kanai Y  et al. KIF13B enhances the endocytosis of LRP1 by recruiting LRP1 to caveolae. J Cell Biol 204:395-408 (2014). Mouse . PubMed: 24469637
  • Niesman IR  et al. Traumatic brain injury enhances neuroinflammation and lesion volume in caveolin deficient mice. J Neuroinflammation 11:39 (2014). WB ; Mouse . PubMed: 24593993
  • Schorch B  et al. LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins. Proc Natl Acad Sci U S A 111:6431-6 (2014). WB, ICC/IF ; Mouse . PubMed: 24737893
  • Hasegawa H  et al. The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-ß precursor. Nat Commun 5:3917 (2014). PubMed: 24894631
  • Yang J  et al. Recurrent LRP1-SNRNP25 and KCNMB4-CCND3 fusion genes promote tumor cell motility in human osteosarcoma. J Hematol Oncol 7:76 (2014). WB, IHC ; Human . PubMed: 25300797
  • Cal R  et al. Aggregated low-density lipoprotein induces LRP1 stabilization through E3 ubiquitin ligase CHFR downregulation in human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 33:369-77 (2013). WB ; Human . PubMed: 23241409
  • Drevinge C  et al. Cholesteryl esters accumulate in the heart in a porcine model of ischemia and reperfusion. PLoS One 8:e61942 (2013). WB ; Pig . PubMed: 23637933
  • Messmer MN  et al. Identification of the cellular sentinels for native immunogenic heat shock proteins in vivo. J Immunol 191:4456-65 (2013). PubMed: 24048898
  • Kim HJ  et al. The hypolipidemic effect of cilostazol can be mediated by regulation of hepatic low-density lipoprotein receptor-related protein 1 (LRP1) expression. Metabolism N/A:N/A (2013). IHC ; Mouse, Human . PubMed: 24139096
  • Huang G  et al. Insulin responsiveness of glucose transporter 4 in 3T3-L1 cells depends on the presence of sortilin. Mol Biol Cell 24:3115-22 (2013). WB . PubMed: 23966466
  • Yang W  et al. Aquaporin-4 mediates astrocyte response to ß-amyloid. Mol Cell Neurosci 49:406-414 (2012). WB ; Mouse . PubMed: 22365952
  • Hayashi H  et al. A potential neuroprotective role of apolipoprotein E-containing lipoproteins through low density lipoprotein receptor-related protein 1 in normal tension glaucoma. J Biol Chem 287:25395-406 (2012). WB, ICC/IF, IP ; Rat . PubMed: 22674573
  • Erickson MA  et al. Peripheral administration of antisense oligonucleotides targeting the amyloid-ß protein precursor reverses AßPP and LRP-1 overexpression in the aged SAMP8 mouse brain. J Alzheimers Dis 28:951-60 (2012). WB ; Mouse . PubMed: 22179572
  • Jiang R  et al. Apo- and holo-lactoferrin are both internalized by lactoferrin receptor via clathrin-mediated endocytosis but differentially affect ERK-signaling and cell proliferation in Caco-2 cells. J Cell Physiol 226:3022-31 (2011). WB ; Human . PubMed: 21935933
  • Kovac A  et al. Brain microvascular pericytes are immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in response to lipopolysaccharide. J Neuroinflammation 8:139 (2011). WB ; Mouse . PubMed: 21995440


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