FunctionProbable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor.
Tissue specificityWidely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas, but not in tissues consisting of a large number of epithelial cells, such as liver and kidney. Expressed at very low levels in a number of tumor-derived cell lines.
Sequence similaritiesBelongs to the LDLR family. Contains 2 CUB domains. Contains 5 LDL-receptor class A domains.