Anti-Lrp2 / Megalin antibody (ab115316)


  • Product nameAnti-Lrp2 / Megalin antibody
    See all Lrp2 / Megalin primary antibodies
  • Description
    Rabbit polyclonal to Lrp2 / Megalin
  • Tested applicationsSuitable for: ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide, conjugated to KLH, from a region of Human Lrp2/Megalin.

  • Positive control
    • Human kidney cortex tissue


Our Abpromise guarantee covers the use of ab115316 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1 - 1/1000.
IHC-P Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.


  • FunctionActs together with cubilin to mediate HDL endocytosis (By similarity). May participate in regulation of parathyroid-hormone and para-thyroid-hormone-related protein release.
  • Tissue specificityAbsorptive epithelia, including renal proximal tubules.
  • Involvement in diseaseDefects in LRP2 are the cause of Donnai-Barrow syndrome (DBS) [MIM:222448]; also known as faciooculoacousticorenal syndrome (FOAR syndrome). DBS is a rare autosomal recessive disorder characterized by major malformations including agenesis of the corpus callosum, congenital diaphragmatic hernia, facial dysmorphology, ocular anomalies, sensorineural hearing loss and developmental delay. The FOAR syndrome was first described as comprising facial anomalies, ocular anomalies, sensorineural hearing loss, and proteinuria. DBS and FOAR were first described as distinct disorders but the classic distinguishing features between the 2 disorders were presence of proteinuria and absence of diaphragmatic hernia and corpus callosum anomalies in FOAR. Early reports noted that the 2 disorders shared many phenotypic features and may be identical. Although there is variability in the expression of some features (e.g. agenesis of the corpus callosum and proteinuria), DBS and FOAR are now considered to represent the same entity.
  • Sequence similaritiesBelongs to the LDLR family.
    Contains 17 EGF-like domains.
    Contains 36 LDL-receptor class A domains.
    Contains 37 LDL-receptor class B repeats.
  • Cellular localizationMembrane. Membrane > coated pit.
  • Information by UniProt
  • Database links
  • Alternative names
    • Calcium sensor protein antibody
    • DBS antibody
    • Glycoprotein 330 antibody
    • gp330 antibody
    • Heymann nephritis antigen homolog antibody
    • Low-density lipoprotein receptor-related protein 2 antibody
    • LRP-2 antibody
    • Lrp2 antibody
    • LRP2_HUMAN antibody
    • Megalin antibody
    see all

Anti-Lrp2 / Megalin antibody images

  • ab115316 at 2.5ug/ml staining Lrp2/Megalin in Human kidney cortex tissue by immunohistochemistry. Following primary incubation the slides were incubated with biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References for Anti-Lrp2 / Megalin antibody (ab115316)

ab115316 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your reply. Your discount code for testing ab76969 on non-human primate is ***. This code will expire on June 6th, 2012. Please let me know if you need any additional assistance.

Expiration date: June 2nd, 2012

I am very pleased to hear you would like to accept our offer and test ab115316 in non-human primate. This code will give you 1 freeprimary antibodybefore the expiration date. To redeem t...

Read More