The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
FunctionProbable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro.
Tissue specificityWidely expressed. Highly expressed in skeletal muscle and ovary. Expressed at intermediate level in heart, brain, liver, pancreas, prostate and small intestine. Weakly expressed in testis, colon and leukocyte.
Sequence similaritiesBelongs to the LDLR family. Contains 2 CUB domains. Contains 4 LDL-receptor class A domains.
Immunohistochemistry Image of Human Skin (formalin-fixed, paraffin-embedded) stained with LRP3 antibody (ab115197) at 10 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
References for Anti-LRP3 antibody (ab115197)
has not yet been referenced specifically in any publications.
Publishing research using ab115197? Please let us know so that we can cite the reference in this datasheet.
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