Overview

  • Product nameAnti-LRP4 antibody
    See all LRP4 primary antibodies
  • Description
    Goat polyclonal to LRP4
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to an internal region of Human LRP4.

  • Positive control
    • Human Colon, Epithelium tissue; Human cerebral cortex lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab122923 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 212 kDa.
IHC-P Use a concentration of 3.75 µg/ml.

Target

  • FunctionPotential cell surface endocytic receptor, which binds and internalizes extracellular ligands for degradation by lysosomes. Involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway.
  • Tissue specificityExpressed in several regions of the brain.
  • Involvement in diseaseDefects in LRP4 are the cause of Cenani-Lenz syndactyly syndrome (CLSS) [MIM:212780]. It is a congenital malformation syndrome defined as complete and complex syndactyly of the hands combined with malformations of the forearm bones and similar manifestations in the lower limbs.
  • Sequence similaritiesBelongs to the LDLR family.
    Contains 3 EGF-like domains.
    Contains 8 LDL-receptor class A domains.
    Contains 20 LDL-receptor class B repeats.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Corin antibody
    • KIAA0816 antibody
    • LDLR dan antibody
    • Low density lipoprotein receptor related protein 4 antibody
    • Low-density lipoprotein receptor-related protein 4 antibody
    • LRP-4 antibody
    • LRP10 antibody
    • Lrp4 antibody
    • LRP4_HUMAN antibody
    • MEGF7 antibody
    • Multiple epidermal growth factor like domains 7 antibody
    • Multiple epidermal growth factor-like domains 7 antibody
    see all

Anti-LRP4 antibody images

  • ab122923, at 3.75 µg/ml, staining LRP4 in Formalin-fixed, Paraffin-embedded Human Colon, epithelium tissue by Immunohistochemistry.
  • Anti-LRP4 antibody (ab122923) at 0.1 µg/ml + Human cerebral cortex lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 212 kDa

References for Anti-LRP4 antibody (ab122923)

ab122923 has not yet been referenced specifically in any publications.

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