Overview

  • Product nameAnti-LRP4 antibody
    See all LRP4 primary antibodies
  • Description
    Goat polyclonal to LRP4
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Synthetic peptide:

    C-SNPSYRTSTQEVK

    , corresponding to internal sequence amino acids 1765-1777 of Human LRP4 (NP_002325.2).

  • Positive control
    • Human brain (cerebral cortex) lysate.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris saline, pH 7.3
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesab85697 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab85697 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 200 kDa (predicted molecular weight: 216 kDa).

Target

  • FunctionPotential cell surface endocytic receptor, which binds and internalizes extracellular ligands for degradation by lysosomes. Involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway.
  • Tissue specificityExpressed in several regions of the brain.
  • Involvement in diseaseDefects in LRP4 are the cause of Cenani-Lenz syndactyly syndrome (CLSS) [MIM:212780]. It is a congenital malformation syndrome defined as complete and complex syndactyly of the hands combined with malformations of the forearm bones and similar manifestations in the lower limbs.
  • Sequence similaritiesBelongs to the LDLR family.
    Contains 3 EGF-like domains.
    Contains 8 LDL-receptor class A domains.
    Contains 20 LDL-receptor class B repeats.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Corin antibody
    • KIAA0816 antibody
    • LDLR dan antibody
    • Low density lipoprotein receptor related protein 4 antibody
    • Low-density lipoprotein receptor-related protein 4 antibody
    • LRP-4 antibody
    • LRP10 antibody
    • Lrp4 antibody
    • LRP4_HUMAN antibody
    • MEGF7 antibody
    • Multiple epidermal growth factor like domains 7 antibody
    • Multiple epidermal growth factor-like domains 7 antibody
    see all

Anti-LRP4 antibody images

References for Anti-LRP4 antibody (ab85697)

This product has been referenced in:
  • Ohkawara B  et al. LRP4 third ß-propeller domain mutations cause novel congenital myasthenia by compromising agrin-mediated MuSK signaling in a position-specific manner. Hum Mol Genet N/A:N/A (2013). Read more (PubMed: 24234652) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"