Anti-LRP5 + LRP6 antibody (ab51910)

Overview

  • Product nameAnti-LRP5 + LRP6 antibody
  • Description
    Rabbit polyclonal to LRP5 + LRP6
  • SpecificityThe antibody recognizes the ~170 kDa full length LRP-5/6. A cleavage fragment (~120 kDa) can also be detected.
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide surrounding amino acid 437 of LRP (Human)

  • Positive control
    • Jurkat cell lysate

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab51910 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 4 µg/ml. Predicted molecular weight: 179 kDa.

Target

  • RelevanceLDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading Axin degradation and beta catenin stabilization.
  • Cellular localizationMembrane; single-pass type I membrane protein
  • Database links
  • Alternative names
    • BMND1 antibody
    • EVR 4 antibody
    • EVR1 antibody
    • EVR4 antibody
    • HBM antibody
    • Low density lipoprotein receptor related protein 5 antibody
    • Low density lipoprotein receptor related protein 6 antibody
    • LR3 antibody
    • LRP7 antibody
    • OPPG antibody
    • OPS antibody
    • OPTA1 antibody
    • VBCH2 antibody
    see all

Anti-LRP5 + LRP6 antibody images

  • All lanes : Anti-LRP5 + LRP6 antibody (ab51910) at 4 µg/ml

    Lane 1 : Jurkat cell lysate at 100 µg
    Lane 2 : Jurkat cell lysate at 50 µg

    Secondary
    HRP conjugated goat anti rabbit IgG

    Predicted band size : 179 kDa
    Observed band size : 190 kDa (why is the actual band size different from the predicted?)

References for Anti-LRP5 + LRP6 antibody (ab51910)

ab51910 has not yet been referenced specifically in any publications.

Product Wall


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