Overview

  • Product nameLRP5 + LRP6 peptide

Description

  • NatureSynthetic

Specifications

Our Abpromise guarantee covers the use of ab51923 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Purity> 90 % SDS-PAGE.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • BMND1
    • EVR 4
    • EVR1
    • EVR4
    • HBM
    • Low density lipoprotein receptor related protein 5
    • Low density lipoprotein receptor related protein 6
    • LR3
    • LRP7
    • OPPG
    • OPS
    • OPTA1
    • VBCH2
    see all
  • RelevanceLDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading Axin degradation and beta catenin stabilization.
  • Cellular localizationMembrane; single-pass type I membrane protein

References for LRP5 + LRP6 peptide (ab51923)

ab51923 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"