Overview

  • Product name
  • Description
    Rabbit polyclonal to LRRC26
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Cow, Dog
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 209-258 (LRPLCAWLRR HPLPASEAET VLCVWPGRLT LSPLTAFSDA AFSHCAQPLA) of Human LRRC26 (NP_001013675).

  • Positive control
    • Jurkat cell lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab105838 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.25 µg/ml. Predicted molecular weight: 35 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function
    Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low-voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium.
  • Tissue specificity
    Isoform 1 is expressed highly in normal prostate and salivary gland, very weakly in colon, pancreas, and intestine, and not at all in other tissues. Isoform 1 is expressed highly in many cancer cell lines and in breast cancer, pancreatic cancer and colon cancer. Isoform 2 is expressed in cancer cell lines.
  • Sequence similarities
    Contains 5 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 LRRNT domain.
  • Domain
    The transmembrane domain is necessary for interaction with KCNMA1.
  • Cellular localization
    Membrane. Cytoplasm > cytoskeleton. Although predicted to be a single-pass type I membrane protein, this protein localizes to the cytoplasm when expressed at high levels.
  • Information by UniProt
  • Database links
  • Form
    There are 2 isoforms produced by alternative splicing. Isoform 1 = L-CAPC. Isoform 2 = S-CAPC and does not contain the immunogen sequence.
  • Alternative names
    • bA350O14.10 antibody
    • CAPC antibody
    • cytokeratin-associated protein antibody
    • Cytokeratin-associated protein in cancer antibody
    • Leucine-rich repeat-containing protein 26 antibody
    • LRC26_HUMAN antibody
    • Lrrc26 antibody
    see all

Images

  • All lanes : Anti-LRRC26 antibody (ab105838) at 0.25 µg/ml

    Lane 1 : molecular weight markers
    Lane 2 : Jurkat cell lysate at 10 µg


    Predicted band size : 35 kDa

References

ab105838 has not yet been referenced specifically in any publications.

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There are currently no Customer reviews or Questions for ab105838.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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