Overview

  • Product name
  • Description
    Rabbit polyclonal to LRRC8A
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Dog, Pig
  • Immunogen

    Recombinant fragment, corresponding to amino acids 648-803 of Human LRRC8A (BC051322).

  • Positive control
    • Human fetal liver, Jurkat and A549 cell lysates; Human fetal kidney tissue.

Properties

  • Form
    Lyophilised:Reconstitute with 200ul distilled sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    pH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 98% PBS, 1% BSA
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab157489 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 94 kDa.
IHC-P 1/100 - 1/500.

Target

  • Function
    Involved in B-cell development. Required for the pro-B cell to pre-B cell transition.
  • Tissue specificity
    Expressed in brain, kidney, ovary, lung, liver, heart, and fetal brain and liver. Found at high levels in bone marrow; lower levels are detected in peripheral blood cells. Expressed on T-cells as well as on B-lineage cells.
  • Involvement in disease
    Defects in LRRC8A are the cause of agammaglobulinemia type 5 (AGM5) [MIM:613506]. It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. Note=A chromosomal aberration involving LRRC8 has been found in a patient with congenital agammaglobulinemia. Translocation t(9;20)(q33.2;q12). The translocation truncates the LRRC8 gene, resulting in deletion of the eighth, ninth, and half of the seventh LRR domains.
  • Sequence similarities
    Contains 17 LRR (leucine-rich) repeats.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • AGM5 antibody
    • FLJ10337 antibody
    • FLJ41617 antibody
    • KIAA1437 antibody
    • Leucine rich repeat containing 8 family member A antibody
    • Leucine rich repeat containing protein 8A antibody
    • Leucine-rich repeat-containing protein 8A antibody
    • LRC8A_HUMAN antibody
    • LRRC8 antibody
    • Lrrc8a antibody
    see all

Images

  • All lanes : Anti-LRRC8A antibody (ab157489) at 1/500 dilution

    Lane 1 : Human fetal liver lysate
    Lane 2 : Jurkat cell lysate
    Lane 3 : A549 cell lysate

    Predicted band size: 94 kDa

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human fetal kidney tissue labeling LRRC8A with ab157489 at 1/100 dilution.

References

ab157489 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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