• Product nameAnti-LRRC8A antibody
    See all LRRC8A primary antibodies
  • Description
    Rabbit polyclonal to LRRC8A
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 2-51 (IPVTELRYFA DTQPAYRILK PWWDVFTDYI SIVMLMIAVF GGTLQVTQDK) of Human LRRC8A (NP_062540).

  • Positive control
    • Jurkat cell lysate.


  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas


Our Abpromise guarantee covers the use of ab81135 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 94 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

Titre using peptide based assay: 1/62500.


  • FunctionInvolved in B-cell development. Required for the pro-B cell to pre-B cell transition.
  • Tissue specificityExpressed in brain, kidney, ovary, lung, liver, heart, and fetal brain and liver. Found at high levels in bone marrow; lower levels are detected in peripheral blood cells. Expressed on T-cells as well as on B-lineage cells.
  • Involvement in diseaseDefects in LRRC8A are the cause of agammaglobulinemia type 5 (AGM5) [MIM:613506]. It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. Note=A chromosomal aberration involving LRRC8 has been found in a patient with congenital agammaglobulinemia. Translocation t(9;20)(q33.2;q12). The translocation truncates the LRRC8 gene, resulting in deletion of the eighth, ninth, and half of the seventh LRR domains.
  • Sequence similaritiesContains 17 LRR (leucine-rich) repeats.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • AGM5 antibody
    • FLJ10337 antibody
    • FLJ41617 antibody
    • KIAA1437 antibody
    • Leucine rich repeat containing 8 family member A antibody
    • Leucine rich repeat containing protein 8A antibody
    • Leucine-rich repeat-containing protein 8A antibody
    • LRC8A_HUMAN antibody
    • LRRC8 antibody
    • Lrrc8a antibody
    see all

Anti-LRRC8A antibody images

  • Anti-LRRC8A antibody (ab81135) at 1 µg/ml (in 5% skim milk / PBS buffer) + Jurkat cell lysate at 10 µg

    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 94 kDa

References for Anti-LRRC8A antibody (ab81135)

ab81135 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab81135.
Please use the links above to contact us or submit feedback about this product.