Overview

  • Product name
  • Description
    Rabbit polyclonal to LRRTM2
  • Specificity
    ab133208 is predicted to not cross-react with other LRRTM family members.
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide, corresponding to C terminal amino acids of Human LRRTM2.

  • Positive control
    • Human brain cortex tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab133208 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 59 kDa.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B.
  • Tissue specificity
    Expressed in neuronal tissues.
  • Sequence similarities
    Belongs to the LRRTM family.
    Contains 10 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 LRRNT domain.
  • Domain
    Synaptogenic effects are mediated by the extracellular LRR region.
  • Cellular localization
    Cell membrane. Cell junction > synapse > postsynaptic cell membrane. Localized to excitatory synapses.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ76283 antibody
    • FLJ99831 antibody
    • KIAA0416 antibody
    • Leucine rich repeat transmembrane neuronal 2 antibody
    • Leucine rich repeat transmembrane neuronal 2 protein antibody
    • Leucine rich repeat transmembrane protein 2 antibody
    • Leucine-rich repeat neuronal 2 protein antibody
    • Leucine-rich repeat transmembrane neuronal protein 2 antibody
    • LRRN2 antibody
    • LRRT2_HUMAN antibody
    • Lrrtm2 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain cortex tissue labelling LRRTM2 with ab133208 at 5 µg/ml, followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References

ab133208 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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