Overview

  • Product nameAnti-LRSAM1 antibody
    See all LRSAM1 primary antibodies
  • Description
    Mouse polyclonal to LRSAM1
  • Tested applicationsSuitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length Human protein

  • Positive control
    • Human liver tissue lysate; LRSAM1-transfected 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab73113 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.
WB 1/500 - 1/1000. Predicted molecular weight: 84 kDa.

Target

  • FunctionE3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos.
  • Tissue specificityHighly expressed in adult spinal cord motoneurons as well as in fetal spinal cord and muscle tissue.
  • PathwayProtein modification; protein ubiquitination.
  • Involvement in diseaseCharcot-Marie-Tooth disease 2P (CMT2P) [MIM:614436]: An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Sequence similaritiesContains 6 LRR (leucine-rich) repeats.
    Contains 1 RING-type zinc finger.
    Contains 1 SAM (sterile alpha motif) domain.
  • DomainThe coiled coil domains interact with the SB domain of TSG101.
    The PTAP motifs mediate the binding to UEV domains.
  • Cellular localizationCytoplasm. Displays a punctuate distribution and localizes to a submembranal ring.
  • Information by UniProt
  • Database links
  • Alternative names
    • CMT2P antibody
    • E3 ubiquitin protein ligase LRSAM1 antibody
    • E3 ubiquitin-protein ligase LRSAM1 antibody
    • EC 6.3.2.- antibody
    • FLJ31641 antibody
    • hTAL antibody
    • Leucine rich repeat and sterile alpha motif containing 1 antibody
    • Leucine rich repeat and sterile alpha motif containing protein 1 antibody
    • Leucine-rich repeat and sterile alpha motif-containing protein 1 antibody
    • LRSAM1 antibody
    • LRSM1_HUMAN antibody
    • OTTHUMP00000022174 antibody
    • OTTHUMP00000022175 antibody
    • RIFLE antibody
    • TAL antibody
    • Tsg101 associated ligase antibody
    • Tsg101-associated ligase antibody
    see all

Anti-LRSAM1 antibody images

  • Anti-LRSAM1 antibody (ab73113) at 1/500 dilution + Human liver tissue lysate at 25 µg

    Secondary
    HRP-conjugated Goat Anti-Mouse IgG at 1/2500 dilution

    Predicted band size : 84 kDa
    Observed band size : 84 kDa
  • All lanes : Anti-LRSAM1 antibody (ab73113) at 1/500 dilution

    Lane 1 : LRSAM1-transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    HRP-conjugated Goat Anti-Mouse IgG at 1/2500 dilution

    Predicted band size : 84 kDa
    Observed band size : 84 kDa

References for Anti-LRSAM1 antibody (ab73113)

This product has been referenced in:
  • Nicolaou P  et al. A novel LRSAM1 mutation is associated with autosomal dominant axonal Charcot-Marie-Tooth disease. Eur J Hum Genet : (2012). Human . Read more (PubMed: 22781092) »
  • Guernsey DL  et al. Mutation in the gene encoding ubiquitin ligase LRSAM1 in patients with Charcot-Marie-Tooth disease. PLoS Genet 6: (2010). WB ; Human . Read more (PubMed: 20865121) »

See all 2 Publications for this product

Product Wall

There are currently no Abreviews or Questions for ab73113.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"