This fast track antibody is not yet fully characterized. It is subject to these terms and conditions

Overview

Properties

Applications

  • Application notesThis antibody gave a positive result in ELISA against the immunizing peptide (ab34463).
    Not yet tested in other applications.

  • Target

    • FunctionHistone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4.
    • Sequence similaritiesBelongs to the flavin monoamine oxidase family.
      Contains 1 CW-type zinc finger.
      Contains 1 SWIRM domain.
    • DomainThe SWIRM domain may act as an anchor site for a histone tail.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • FormThere are 3 isoforms produced by alternative splicing.
    • Alternative names
      • amine oxidase (flavin containing) domain 1 antibody
      • amine oxidase, flavin containing 1 antibody
      • AOF1 antibody
      • bA204B7.3 antibody
      • C6orf193 antibody
      • dJ298J15.2 antibody
      • Flavin-containing amine oxidase domain-containing protein 1 antibody
      • FLJ33898 antibody
      • FLJ34109 antibody
      • FLJ43328 antibody
      • KDM1B antibody
      • KDM1B_HUMAN antibody
      • LSD2 antibody
      • lysine (K)-specific demethylase 1B antibody
      • Lysine-specific demethylase 2 antibody
      • Lysine-specific histone demethylase 1B antibody
      • Lysine-specific histone demethylase 2 antibody
      see all

    References for Anti-LSD2 / AOF1 antibody (ab34464)

    ab34464 has not yet been referenced specifically in any publications.

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