The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 - 10 µg/ml. Predicted molecular weight: 11 kDa.
Use a concentration of 0.5 - 1 µg/ml.
FunctionPossible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation.
Tissue specificityExpressed in lung, tonsil, thymus, placenta, kidney, fetal spleen, fetal liver and brain.
Sequence similaritiesBelongs to the LST1 family.
Cellular localizationMembrane. Golgi apparatus membrane. Endomembrane system. Also detected in a perinuclear region corresponding to the localization of the Golgi apparatus and throughout the cytoplasm.