Anti-LTBP1 antibody [MM0447-5L38] (ab89723)

Overview

  • Product name
    Anti-LTBP1 antibody [MM0447-5L38]
    See all LTBP1 primary antibodies
  • Description
    Mouse monoclonal [MM0447-5L38] to LTBP1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length Human LTBP1.

Properties

Applications

Our Abpromise guarantee covers the use of ab89723 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 187 kDa.

Can only detect the LTBP1 from the latent TGF­β1 complex therefore perform under non-reducing conditions

Target

  • Function
    May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM).
  • Tissue specificity
    Isoform Long is found in fibroblasts.
  • Sequence similarities
    Belongs to the LTBP family.
    Contains 18 EGF-like domains.
    Contains 4 TB (TGF-beta binding) domains.
  • Domain
    Associates covalently with small latent TGF-beta complex via domain TB 3.
  • Post-translational
    modifications
    Contains hydroxylated asparagine residues.
    Isoform Short N-terminus is blocked.
    The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • 9430031G15Rik antibody
    • 9830146M04 antibody
    • Latent transforming growth factor beta binding protein 1 antibody
    • Latent-transforming growth factor beta-binding protein 1 antibody
    • Latent-transforming growth factor beta-binding protein, isoform 1L antibody
    • Latent-transforming growth factor beta-binding protein, isoform 1S antibody
    • LBT1S antibody
    • LTBP-1 antibody
    • Ltbp1 antibody
    • LTBP1_HUMAN antibody
    • MGC163161 antibody
    • TGF-beta1-BP-1 antibody
    • Tgfb antibody
    • Transforming growth factor beta-1-binding protein 1 antibody
    • Transforming growth factor beta-1-masking protein large subunit antibody
    see all

References

ab89723 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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