Can only detect the LTBP1 from the latent TGFβ1 complex therefore perform under non-reducing conditions
FunctionMay be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM).
Tissue specificityIsoform Long is found in fibroblasts.
Sequence similaritiesBelongs to the LTBP family. Contains 18 EGF-like domains. Contains 4 TB (TGF-beta binding) domains.
DomainAssociates covalently with small latent TGF-beta complex via domain TB 3.
Post-translational modificationsContains hydroxylated asparagine residues. Isoform Short N-terminus is blocked. The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.