Overview

  • Product nameAnti-LTBP2 antibody
    See all LTBP2 primary antibodies
  • Description
    Goat polyclonal to LTBP2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity

    Predicted to work with: Mouse, Human
  • Immunogen

    Synthetic peptide:

    C-NSTSSTEDLPDHD

    with a Cysteine residue linker, corresponding to internal sequence amino acids 1568-1580 of Human LTBP2 (NP_000419.1).

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferpH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesPurified from Goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab121005 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 195 kDa. Preliminary experiments in Mouse and Rat Eye lysates gave no specific signal but low background (at antibody concentration up to 1µg/ml).

Target

  • FunctionMay play an integral structural role in elastic-fiber architectural organization and/or assembly.
  • Tissue specificityExpressed in lung, weakly expressed in heart, placenta, liver and skeletal muscle.
  • Involvement in diseaseDefects in LTBP2 are the cause of primary congenital glaucoma type 3D (GLC3D) [MIM:613086]. An autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early childhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor.
    Defects in LTBP2 are the cause of microspherophakia (MCSPH) [MIM:251750]. It is a rare disease characterized by smaller and more spherical lenses than normal bilaterally, an increased anteroposterior thickness of the lens and highly myopic eyes. Lens dislocation or subluxation may occur, leading to defective accommodation.
  • Sequence similaritiesBelongs to the LTBP family.
    Contains 20 EGF-like domains.
    Contains 4 TB (TGF-beta binding) domains.
  • DomainAssociates covalently with small latent TGF-beta complex via Repeat B and Repeat C.
  • Post-translational
    modifications
    Contains hydroxylated asparagine residues.
  • Cellular localizationSecreted. Localized in nuchal ligament and aorta to the fibrillin-containing, microfibrillar component of elastic fibers.
  • Information by UniProt
  • Database links
  • Alternative names
    • C14orf141 antibody
    • Chromosome 14 open reading frame 141 antibody
    • Latent TGF beta binding protein 2 antibody
    • Latent transforming growth factor beta binding protein 2 antibody
    • Latent-transforming growth factor beta-binding protein 2 antibody
    • LTBP 2 antibody
    • LTBP 3 antibody
    • LTBP-2 antibody
    • Ltbp2 antibody
    • LTBP2_HUMAN antibody
    • LTBP3 antibody
    • MSTP 031 antibody
    • MSTP031 antibody
    see all

References for Anti-LTBP2 antibody (ab121005)

ab121005 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"