Overview

  • Product name
  • Description
    Rabbit polyclonal to LTBP2
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence, corresponding to internal sequence amino acids 241-376 of Human LTBP2.

  • Positive control
    • Human prostate tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab121193 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/800. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    May play an integral structural role in elastic-fiber architectural organization and/or assembly.
  • Tissue specificity
    Expressed in lung, weakly expressed in heart, placenta, liver and skeletal muscle.
  • Involvement in disease
    Defects in LTBP2 are the cause of primary congenital glaucoma type 3D (GLC3D) [MIM:613086]. An autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early childhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor.
    Defects in LTBP2 are the cause of microspherophakia (MCSPH) [MIM:251750]. It is a rare disease characterized by smaller and more spherical lenses than normal bilaterally, an increased anteroposterior thickness of the lens and highly myopic eyes. Lens dislocation or subluxation may occur, leading to defective accommodation.
  • Sequence similarities
    Belongs to the LTBP family.
    Contains 20 EGF-like domains.
    Contains 4 TB (TGF-beta binding) domains.
  • Domain
    Associates covalently with small latent TGF-beta complex via Repeat B and Repeat C.
  • Post-translational
    modifications
    Contains hydroxylated asparagine residues.
  • Cellular localization
    Secreted. Localized in nuchal ligament and aorta to the fibrillin-containing, microfibrillar component of elastic fibers.
  • Information by UniProt
  • Database links
  • Alternative names
    • C14orf141 antibody
    • Chromosome 14 open reading frame 141 antibody
    • Latent TGF beta binding protein 2 antibody
    • Latent transforming growth factor beta binding protein 2 antibody
    • Latent-transforming growth factor beta-binding protein 2 antibody
    • LTBP 2 antibody
    • LTBP 3 antibody
    • LTBP-2 antibody
    • Ltbp2 antibody
    • LTBP2_HUMAN antibody
    • LTBP3 antibody
    • MSTP 031 antibody
    • MSTP031 antibody
    see all

Anti-LTBP2 antibody images

  • ab121193 at 1/800 dilution staining LTBP2 in Paraffin-embedded Human Prostate tissue by Immunohistochemistry.

References for Anti-LTBP2 antibody (ab121193)

This product has been referenced in:
  • Wang C  et al. Latent Transforming Growth Factor ß Binding Protein 2 (LTBP2) as a Novel Biomarker for the Diagnosis and Prognosis of Pancreatic Carcinoma. Med Sci Monit 23:3232-3239 (2017). IHC-P ; Human . Read more (PubMed: 28669978) »
  • Zhou X  et al. CACNA1B (Cav2.2) Overexpression and Its Association with Clinicopathologic Characteristics and Unfavorable Prognosis in Non-Small Cell Lung Cancer. Dis Markers 2017:6136401 (2017). Read more (PubMed: 28127114) »

See all 2 Publications for this product

Product Wall

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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