Anti-LTBR antibody [5G11] (ab65089)
Key features and details
- Rat monoclonal [5G11] to LTBR
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Isotype: IgG2a
Overview
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Product name
Anti-LTBR antibody [5G11]
See all LTBR primary antibodies -
Description
Rat monoclonal [5G11] to LTBR -
Host species
Rat -
Tested applications
Suitable for: Flow Cytmore details
Unsuitable for: IHC-Fr or IHC-P -
Species reactivity
Reacts with: Mouse -
Immunogen
Fusion protein corresponding to LTBR. Please refer to the reference below.
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General notes
This antibody is an agonist of LTBR in vitro and is provided in a low endotoxin format.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at +4°C. -
Storage buffer
Constituents: PBS, 0.1% BSA -
Concentration information loading...
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Purity
Protein G purified -
Purification notes
ab65089 was 0.2µm filtered. -
Primary antibody notes
This antibody is an agonist of LTBR in vivo. -
Clonality
Monoclonal -
Clone number
5G11 -
Isotype
IgG2a -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab65089 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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Flow Cyt |
1/50.
ab18450 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
Notes |
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Flow Cyt
1/50. ab18450 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
Target
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Function
Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs. -
Sequence similarities
Contains 4 TNFR-Cys repeats. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 17000 Mouse
- SwissProt: P50284 Mouse
- Unigene: 3122 Mouse
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Alternative names
- CD18 antibody
- D12S370 antibody
- LT beta R antibody
see all
Images
Datasheets and documents
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Datasheet download
References (8)
ab65089 has been referenced in 8 publications.
- Qu F et al. LncRNA HOXA-AS3 promotes gastric cancer progression by regulating miR-29a-3p/LTßR and activating NF-?B signaling. Cancer Cell Int 21:118 (2021). PubMed: 33602223
- Chen M et al. TRIM14 Promotes Noncanonical NF-?B Activation by Modulating p100/p52 Stability via Selective Autophagy. Adv Sci (Weinh) 7:1901261 (2020). PubMed: 31921549
- Choi SY et al. YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells. Nat Commun 11:519 (2020). PubMed: 31980640
- Meena NK et al. mTORC1 activation in B cells confers impairment of marginal zone microarchitecture by exaggerating cathepsin activity. Immunology 155:505-518 (2018). PubMed: 30144045
- Zhao J et al. Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-?B activation. PLoS Biol 16:e2004663 (2018). PubMed: 29889904
- Allen E et al. Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation. Sci Transl Med 9:N/A (2017). PubMed: 28404866
- Gray CM et al. Noncanonical NF-?B signaling is limited by classical NF-?B activity. Sci Signal 7:ra13 (2014). PubMed: 24497610
- Hehlgans T et al. Activation of the lymphotoxin-beta receptor induces NFkappaB-dependent interleukin-6 and MIP-2 secretion in mouse fibrosarcoma cells. Eur Cytokine Netw 14:103-7 (2003). PubMed: 12957791