Overview

  • Product nameAnti-LTK antibody
    See all LTK primary antibodies
  • Description
    Rabbit polyclonal to LTK
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to a region within amino acids 800-864 of Human LTK, conjugated to KLH.

  • Positive control
    • Human colon, lamina propria plasma cells

Properties

Applications

Our Abpromise guarantee covers the use of ab115273 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 2 - 5 µg/ml. Predicted molecular weight: 92 kDa.
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionOrphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport.
  • Tissue specificityExpressed in non-hematopoietic cell lines and T- and B-cell lines.
  • Involvement in diseaseNote=Genetic variations in LTK that cause up-regulation of the PI3K pathway may possibly contribute to susceptibility to abnormal proliferation of self-reactive B cells and, therefore, to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue, thought to represent a failure of the regulatory mechanisms of the autoimmune system.
  • Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
    Contains 1 protein kinase domain.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Leukocyte receptor tyrosine kinase antibody
    • Leukocyte tyrosine kinase antibody
    • Leukocyte tyrosine kinase receptor antibody
    • Ltk antibody
    • LTK_HUMAN antibody
    • Protein tyrosine kinase 1 antibody
    • TYK 1 antibody
    • TYK1 antibody
    see all

Anti-LTK antibody images

  • Human colon lamina propria plasma cells (formalin fixed, paraffin embedded) stained with ab115273 at 10 µg/ml, followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References for Anti-LTK antibody (ab115273)

ab115273 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"